Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva Saliva. salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
Evaluation of the efficacy of oral nano-silymarin formulation in hospitalized patients with COVID-19: A double-blind placebo-controlled clinical trialArticle Published on 2022-10-012022-11-15 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] alanine aminotransferase Anti-viral Antiviral assigned baseline clinical trial Concomitant COVID-19 cytokine release Cytokine release syndrome Dexamethasone dosage double-blind Effect effective Effectiveness Efficacy Evidence follow-up period gel Hospitalization hospitalized patient Laboratory Laboratory parameters lack liver enzyme management outbreak pandemic participant Patient patients with COVID-19 placebo group placebo-controlled clinical trial receiving Remdesivir sample sizes SARS-CoV-2 significant difference significantly silymarin. Symptom the placebo group therapeutic strategy Treatment treatment group two group viral disease were assessed [DOI] 10.1002/ptr.7537 PMC 바로가기
The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled TrialArticle Published on 2022-09-192022-11-16 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] age Analysis Anti-inflammatory Asymptomatic Cluster control group Controlled Course COVID-19 COVID-19 cases demonstrated different dose differentiation disease dose double-blind Effect Final FIVE Gender group groups Inflammatory Inflammatory marker Intervention investigated marker Mild mild COVID-19 Nigella Nigella Sativa parameter Patient patients with COVID-19 placebo-controlled clinical trial procalcitonin profile randomized clinical trial randomized clinical trial. Randomly SARS-COV-2 infection Saudi Arabia Seven significant difference significant effect subject Symptoms Treatment WBC were assessed while [DOI] 10.3390/ijerph191811798 PMC 바로가기
A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis-ICE-COVIDArticle Published on 2022-09-152022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] 1:1 applied carrageenan clinical trial COVID-19 COVID-19 infection COVID-19. demonstrated double-blind double-blinded Effect effective Efficacy expressed General population host cell surface host cells in vitro activity include Infection infections initial viral load iota-carrageenan kappa-carrageenan nasal Non-COVID-19 nose and throat occur outcome participant penetrate Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial polysaccharide positive PCR Prophylactic Prophylaxis purified questionnaire randomised receptors reduce Research risk SARS-CoV-2 secondary Seroconversion severity severity of COVID-19 shown Sodium chloride Study protocol subsequent Swab Symptom symptom onset thought treatment arm Trial upper respiratory tract utility vaccination Vaccine variant viral entry virus [DOI] 10.1186/s13063-022-06685-z PMC 바로가기
Efficacy and safety of COVID-19 vaccines: A network meta-analysisArticle Published on 2022-09-012022-11-16 Journal: Journal of evidence-based medicine [Category] meta-analysis, SARS, 변종, [키워드] absence B.1.351 variant clinical trial Community COVID-19 COVID-19 infection COVID-19 vaccines database effective Effectiveness Efficacy effort Human investigated Local Meta-analysis Network meta-analysis nonrandomized pandemic participant Pfizer placebo-controlled clinical trial randomized trial reported required safety profile searched Severe COVID-19 Infection Sinopharm the vaccine threshold trials V-01 vaccination Vaccine vaccine. variant variants [DOI] 10.1111/jebm.12492 PMC 바로가기
A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial – implications for therapeutic immune modulationResearch article Published on 2022-08-182022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 변종, 임상, [키워드] 1:1 Activation Adaptive immune response addition adverse event ARCADIA assigned AZD1656 Clinical improvement clinical trial Complete COVID-19 cytokine Czech Republic Day death decrease diabetes diabetic patient diabetic patients dose double-blind duration of hospitalisation Efficacy Excalibur False positive finding Full Analysis Set funding Glucokinase activator group homeostatic hospital hospital discharge hospitalised identify immune Immune cell immune modulation immune response Immunochemistry immunomodulatory effect Immunophenotyping implication indicated Innovation investigated involved less Medicine multicentre nine no difference Patient phase Phase 2 Placebo placebo-controlled placebo-controlled clinical trial primary analysis primary endpoint pro-inflammatory randomised Randomly receive recruited reduction in Registered regulatory T cells required risk Romania SARS-CoV-2 screened statistically significant difference suggested Tablet the placebo group therapeutic therapeutic effect treated Treatment treatment allocation Tregs Trial usual care with COVID-19 [DOI] 10.1016/j.eclinm.2022.101604 [Article Type] Research article
Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)Favipiravir 및/또는 nitazoxanide: IMSS(FANTAZE)에서 치료를 받는 의료 종사자, 가족 구성원 및 환자를 대상으로 한 COVID-19 조기 치료에 대한 무작위, 이중 맹검, 2x2 설계, 위약 대조 시험Randomized Controlled Trial Published on 2022-07-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 2×2 design absence Admission antimicrobial Antimicrobials Antiviral effect antiviral therapy Antiviral treatment antivirals appear assigned Asymptomatic blinded to treatment combination therapy Comorbidities Comorbidity Controlled trial COVID-19 COVID-19 disease disease double-blind early disease early phase early treatment example Favipiravir followed by Gender Genetic genetic mutation Health high risk Hospitalization Hypothesis in some include individuals Infection Inflammatory Influenza intensive care investigator investigators later phase morbidity and mortality Mutation mutation rate nitazoxanide obesity older patient outcome pandemic participant patients treated pharmacokinetics phase phase IIa Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial positive presence or absence Prevent Primary outcome progression protocol randomised randomised controlled trial Randomised controlled trial. Randomized receive replicates SARS-CoV-2 secondary Secondary outcomes security Sepsis severe disease smoking status Social Security Stratification symptomatic symptomatic COVID-19 Symptoms tested the disease therapy those with comorbidity Toxicity treatment allocation Trial upper respiratory tract Viral load virus [DOI] 10.1186/s13063-022-06533-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
A randomized, placebo-controlled clinical trial evaluating of a mouthwash containing Sambucus williamsii var. coreana extract for prevention of gingivitits Research Published on 2022-07-182022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] applicability assigned Bacteria Care carried conducted Day disease double-blind effective experiment Health healthy homogeneity IBM inhibiting maintain participant patients placebo-controlled clinical trial placebo-controlled study plaque plaques progression Randomized saline solution Sambucus shown significant difference SPSS 24.0 study period two groups USA using a mouthwash VAR was used window [DOI] 10.1038/s41598-022-15445-7 [Article Type] Research